A total of 40,261 people have died in hospitals, care homes and the wider community after testing positive for the virus, up 357 from Thursday.
The UK is only the second country - after the US with 108,000 deaths - to pass the milestone.
In March, the UK's chief scientific adviser said limiting deaths to 20,000 would be a "good outcome".
On asked about assessment, to which Health Secretary Matt Hancock replied that it had been "a time of sorrow for us all".
Each death represents "a family that will never be the same again", he said, adding: "My heart goes out to them all and it makes me redouble my determination to deal with this virus."
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